Matrix(stroma) is included in your study?
- Cell-cell interaction/cell-matrix interaction/integral TME
- 75% quantity
- Mechanical stiffness manisfested as desmoplasia vs. fibrosis vs. elastosis? Hypoxic survival-related changes?
- Edema or myxoid degeneration by activated MMP prior to neovascularization?
Peri/intratumoral inflammatory TME?
- chemo/cytokine by TAM ½
- Double-edged sword for tumor/friend or foe?
Invasion onset biomarker?
- For very early onset of microinvasion? lymphovascular invasion implicaiton?
Metastasis plasticity-differentiation? Molecular similarity?
- Lastency/dormancy? CTC? Colonization?
