Matrix(stroma) is included in your study? 

• Cell-cell interaction/cell-matrix interaction/integral TME
• 75% quantity
• Mechanical stiffness manisfested as desmoplasia vs. fibrosis vs. elastosis? Hypoxic survival-related changes? 
• Edema or myxoid degeneration by activated MMP prior to neovascularization? 

Peri/intratumoral inflammatory TME?

• chemo/cytokine by TAM ½ 
• Double-edged sword for tumor/friend or foe?  

Invasion onset biomarker? 

• For very early onset of microinvasion? lymphovascular invasion implicaiton? 

Metastasis plasticity-differentiation? Molecular similarity?

• Lastency/dormancy? CTC? Colonization?